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It is usually recommended that one 60 mg tablet of evista be taken daily, with or without food.

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The first SERM to reach the market was tamoxifenwhich blocks the stimulative effect of estrogen on breast tissueTamoxifen has proven valuable in preventing cancer in the second breast of women who have had cancer in one breast.

The effect of EVISTA on the incidence of invasive breast cancer was evaluated for 4 additional years in a follow-up study conducted in a subset of postmenopausal women originally enrolled in the MORE osteoporosis treatment trialWomen were not re-randomizedthe treatment assignment from the osteoporosis treatment trial was carried forward to this studyEVISTA60 mg administered once dailyreduced the incidence of invasive breast cancer by 56compared with placeboARR 3.0 per 1000 women-yearsthis was primarily due to a 63reduction in the incidence of ER-positive invasive breast cancer in the EVISTA group compared with placeboThere was no reduction in the incidence of ER-negative breast cancerIn the osteoporosis treatment trial and the follow-up studythere was no difference in incidence of noninvasive breast cancer between the EVISTA and placebo groupsTable 7 presents efficacy and selected safety outcomes.

Evista can also increase your risk of a strokewhich can be fatalThis risk is highest if you have coronary heart disease or certain risk factorssuch as menopausediabetessmokingbeing overweighthaving high blood pressure or high cholesterolhaving a family history of coronary artery diseaseor if you have had a hysterectomy

Across all placebo-controlled trialsEVISTA was indistinguishable from placebo with regard to frequency and severity of breast pain and tendernessEVISTA was associated with less breast pain and tenderness than reported by women receiving estrogens with or without added progestin.

Because these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

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About stuart

Dr. Stuart Samuels is an acclaimed academic (Univ. of Penn: 1968-1981),and a film and television producer, writer, and award-winning documentary filmmaker. (Visions of Light: The Art of Cinematography; Midnight Movies: From The Margin to the Mainstream). His works explore the relationship of popular culture to the broader historical context of their times. Stuart was one of the original writers, Producer, and creative partners on Night Flight. He is developing a Night Flight Series of PopCasts coming soon.